| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8456604 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2011 | 7 Pages |
Abstract
⺠Bimolane, a leukemia-inducing agent, was genotoxic to human lymphocytes in vitro. ⺠Both the synthesized and commercially available drug induced the following. ⺠Chromosomal breakage resulting in micronuclei and dicentric chromosomes. ⺠Aneuploidy as manifested by chromosome loss and non-disjunction. ⺠Polyploidy due to mitotic slippage, endoreduplication and binucleation.
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Authors
Shambhu K. Roy, David A. Eastmond,