| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8456632 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2011 | 5 Pages |
Abstract
⺠We study the genotoxic effects of malathion on Sprague-Dawley rats. ⺠We examine its effects on mitotic index and chromosome structure in bone-marrow cells, and on DNA integrity in leukocytes. ⺠Malathion exposure significantly decreases the mitotic index. ⺠On the other hand, it significantly increases the frequency of structural chromosomal aberrations (SCA) and the percentage of DNA damage, in a dose-dependent manner. ⺠Malathion has a strong clastogenic/genotoxic potential as measured by the SCA and Comet assays.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Pamela D. Moore, Anita K. Patlolla, Paul B. Tchounwou,