Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8456638 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2011 | 15 Pages |
Abstract
⺠In drug development assays for the early detection of genotoxicity are needed. ⺠Two high content screening (HCS) micronucleus assays were developed and validated. ⺠Both HCS assays in HepG2 cells and CHO-k1 cells were able to detect genotoxic potential. ⺠The assays gave a low number of false-positive results. ⺠The assays allow differentiation into clastogens and aneugens.
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Authors
Walter M.A. Westerink, Tom J.J. Schirris, G. Jean Horbach, Willem G.E.J. Schoonen,