Article ID Journal Published Year Pages File Type
8456638 Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2011 15 Pages PDF
Abstract
► In drug development assays for the early detection of genotoxicity are needed. ► Two high content screening (HCS) micronucleus assays were developed and validated. ► Both HCS assays in HepG2 cells and CHO-k1 cells were able to detect genotoxic potential. ► The assays gave a low number of false-positive results. ► The assays allow differentiation into clastogens and aneugens.
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