Genetic alterations affecting the genes encoding the enzymes of the kynurenine pathway and their association with human diseases

Article ID	Journal	Published Year	Pages	File Type
8456688	Mutation Research/Reviews in Mutation Research	2018	14 Pages	PDF

Abstract

To our knowledge, this is the first comprehensive review of the genetic alterations of the KP enzymes. We believe that the identification of genetic alterations underlying diseases has great value regarding both treatment and diagnostics in precision medicine, as this work can promote the understanding of pathological mechanisms, and might facilitate medicinal chemistry approaches to substitute missing components or correct the disturbed metabolite balance of KP.

Keywords

PDS QUIN IDO 3-HAA 3-HK N-methyl-d-aspartate TDO GRE Hemeoxygenase-1 NMDS Kynurenines MDD HO-1 WGS COGA 3-HAO ACMSD 3-Hydroxyanthranilate Collaborative Study on the Genetics of Alcoholism TNF TDO2 Aminocarboxymuconate-semialdehyde decarboxylase PDA Trp NO-cGMP PFC LPS 3-hydroxykynurenine l-Kynurenine NAD+KMO Pancreatic ductal adenocarcinoma Metabolic enzymes Major depressive disorder attention deficit hyperactivity disorder metabolic disturbances xanthurenic acid anthranilic acid kynurenic acid Quinolinic acid interferon IFN indoleamine 2,3-dioxygenase ADHD Alzheimer’s disease Huntington’s disease Parkinson’s disease Crohn’s disease Tryptophan Genetic alterations Whole genome sequencing KYN Spontaneously Hypertensive Rat Tourette syndrome Shr Postpartum depressive symptoms glucocorticoid responsive element tumor necrosis factor prefrontal cortex Lipopolysaccharides CSF Cerebrospinal fluid tryptophan metabolism kynurenine pathway genome wide association studies GWAS Bacterial meningitis Multiple sclerosis Polymorphism Single nucleotide polymorphisms SNP KAT KYNA kynu Kynurenine aminotransferase Kynureninase Glucocorticoid glucocorticoid receptor