Attenuation of multi-targeted proliferation-linked signaling by 3,3′-diindolylmethane (DIM): From bench to clinic

► 3,3′-Diindolylmethane (DIM) is the bioavailable active compound generated in stomach from consumption of cruciferous vegetables. ► DIM has multi-targeted pleiotropic effects in tumor cells sparing normal cells. ► We reviewed cellular, molecular and biological effects of DIM in cancer prevention and therapy. ► DIM is undergoing NIH sponsored clinical trials for prevention and therapy of cancer.