| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8457559 | Nuclear Medicine and Biology | 2018 | 6 Pages |
Abstract
We successfully synthesized l-[3-11C]lactate in a one-pot enzymatic synthetic procedure and showed rapid metabolic conversion of l-[3-11C]lactate to [11C]glucose in the blood. PET analysis of l-[3-11C]lactate indicated the possible presence of active lactate usage in rat brains in vivo.
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![One-pot enzymatic synthesis of l-[3-11C]lactate for pharmacokinetic analysis of lactate metabolism in rat brain](/preview/png/8457559.png "First Page Preview: One-pot enzymatic synthesis of l-[3-11C]lactate for pharmacokinetic analysis of lactate metabolism in rat brain")
Authors
Takashi Temma, Hidekazu Kawashima, Naoya Kondo, Makoto Yamazaki, Kazuhiro Koshino, Hidehiro Iida,