| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8457630 | Nuclear Medicine and Biology | 2018 | 7 Pages |
Abstract
We have developed a radiosynthesis of a novel fluorine-18 labeled bile acid derivative, [18F]FBCGly, and shown by PET/MR that [18F]FBCGly undergoes continuous EHC in rats without metabolizing. This novel tracer may prove useful in PET studies on the effect of drugs or diseases on the EHC of conjugated bile acids.
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![N-(4-[18F]fluorobenzyl)cholylglycine, a novel tracer for PET of enterohepatic circulation of bile acids: Radiosynthesis and proof-of-concept studies in rats](/preview/png/8457630.png "First Page Preview: N-(4-[18F]fluorobenzyl)cholylglycine, a novel tracer for PET of enterohepatic circulation of bile acids: Radiosynthesis and proof-of-concept studies in rats")
Authors
Kim Frisch, Damion H.R. Stimson, Taracad Venkatachalam, Gregory K. Pierens, Susanne Keiding, David Reutens, Rajiv Bhalla,