| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8457655 | Nuclear Medicine and Biology | 2018 | 38 Pages |
Abstract
The results support that these dipeptides, [18F]Gly-4F-Gln and [18F]Ala-4F-Gln, are prodrugs, which hydrolyze in the blood after an iv injection. They appear to be selectively taken up and trapped by tumor tissue in vivo. The dipeptide, [18F]Ala-4F-Gln, may be suitable as a PET tracer for imaging glutaminolysis in tumors.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
![Alanine and glycine conjugates of (2S,4R)-4-[18F]fluoroglutamine for tumor imaging](/preview/png/8457655.png "First Page Preview: Alanine and glycine conjugates of (2S,4R)-4-[18F]fluoroglutamine for tumor imaging")
Authors
Zhihao Zha, Karl Ploessl, Brian P. Lieberman, Limin Wang, Hank F. Kung,