| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8457716 | Nuclear Medicine and Biology | 2018 | 55 Pages |
Abstract
Experimental reference values (logP, Pm, KIAM & PPB) of commonly used PET tracers and drugs showing different BBB penetration behavior are provided. The influence of the logP on brain uptake depends strongly on the selected method. However, using a single parameter (experimental or calculated) to predict BBB penetration or for the classification of drug groups is inexpedient.
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Authors
Chrysoula Vraka, Sanja Mijailovic, Vanessa Fröhlich, Markus Zeilinger, Eva-Maria Klebermass, Wolfgang Wadsak, Karl-Heinz Wagner, Marcus Hacker, Markus Mitterhauser,