| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8457771 | Nuclear Medicine and Biology | 2018 | 31 Pages |
Abstract
The two electrophilic 18F-labeling methods proved to be suitable for synthesis of [18F]NS12137 with the [18F]Selectfluor method providing an approximate three-fold higher yield than the [18F]F2 method. As an electrostatically neutral radiotracer [18F]NS12137 crosses the blood-brain barrier and enabled specific labeling of NET-rich regions of rat brain tissue with the highest concentration in the LCoe.
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![18F-labeled norepinephrine transporter tracer [18F]NS12137: radiosynthesis and preclinical evaluation](/preview/png/8457771.png "First Page Preview: 18F-labeled norepinephrine transporter tracer [18F]NS12137: radiosynthesis and preclinical evaluation")
Authors
Anna K. Kirjavainen, Sarita Forsback, Francisco R. López-Picón, Päivi Marjamäki, Jatta Takkinen, Merja Haaparanta-Solin, Dan Peters, Olof Solin,