Investigation of miR-136-5p key target genes and pathways in lung squamous cell cancer based on TCGA database and bioinformatics analysis

Article ID	Journal	Published Year	Pages	File Type
8458028	Pathology - Research and Practice	2018	11 Pages	PDF

Abstract

Downregulated miR-136-5p may target UGT1A7 and ADH7 and participate in ascorbate and aldarate metabolism, pentose and glucuronate interconversions, and retinol metabolism. High expression of UGT1A7 and ADH7 may indicate better prognosis of LUSC patients.

Keywords

UGT1A9 Smad2 SRD5A1 UGT1A1 EGFR AEG-1 PCT E2F1 CYP19A1 TCGA CYP2B6 Hoxc10 GEPIA GTEx UGT1A4 UGT1A8 UGT1A10 cytochrome P450 family 19 subfamily A member 1 miRNAs Smad3 FDR DFS PPI ALK The cancer genome atlas Disease free survival overall survival SCLC genotype-tissue expression Bioinformatics Molecular function Gene Expression Profiling Interactive Analysis standard error of mean KEGG یا Kyoto Encyclopedia of Genes and Genomes Kyoto Encyclopedia of Genes and Genomes DAVID microRNAs lung adenocarcinoma Large cell lung cancer NSCLC Small cell lung cancer Non-small cell lung cancer E2F transcription factor 1 biological process LUAD SEM Signaling pathway false discovery rate Gene ontology astrocyte elevated gene-1 Target gene Epidermal growth factor receptor LUSC