| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8459390 | Radiotherapy and Oncology | 2017 | 7 Pages |
Abstract
Treating patients with HGG with 50.0â¯Gy photons in 2.0â¯Gy fractions, followed by a proton boost with 10â¯Gy(RBE) in 2.0â¯Gy(RBE) fractions, is safe and feasible. Severe radiation-induced acute toxicity and pseudoprogression were rare in both treatment groups. Therefore, in this clinical setting, combined proton radiotherapy might be beneficial in terms of further risk reduction for treatment-related side effects. Interestingly, treatment volume reduction using a proton boost led to comparable survival and progression rates with decreased severe treatment-related toxicity compared to conventional photon radiotherapy.
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Authors
Sebastian Adeberg, Denise Bernhardt, Semi Ben Harrabi, Matthias Uhl, Angela Paul, Nina Bougatf, Vivek Verma, Andreas Unterberg, Wolfgang Wick, Thomas Haberer, Stephanie E. Combs, Klaus Herfarth, Juergen Debus, Stefan Rieken,