Enhancement of peri-implant bone osteogenic activity induced by a peptidomimetic functionalization of titanium

Fluorochromic bone vital markers were given in a specific time frame, in order to monitor the dynamic of new bone deposition. The effect inducted by the peptidomimetic coating on the surrounding bone were qualitatively and quantitatively evaluated by means of static and dynamic histomorphometric analyses performed within three concentric and subsequent circular Regions of Interest (ROI) of equivalent thickness (220 μm), ROI1 adjacent to the interface, ROI2, the middle, and ROI3 the farthest. The data indicated that these functionalized implants stimulated a higher bone apposition rate (p < 0,01) and larger and rapid osteoblast activation in terms of mineralizing surface within ROI1 compared to the control (p < 0,01). These higher osteoblast recruitment and activation leads to a greater bone-to-implant contact reached for DHVP samples (p < 0,5). This represents an initial stimulus of the osteogenic activity that might results in a faster and better osteointegration process.