Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8460422 | Annals of Anatomy - Anatomischer Anzeiger | 2017 | 8 Pages |
Abstract
PRGF treatment of primary keratinocytes caused a significant concentration- and time-dependent increase of psoriasin gene and protein expression in vitro that were partially mediated by the epidermal growth factor receptor (EGFR) and the interleukin-6 receptor (IL-6R). In accordance with these cell culture data, Vivostat PRF® induced a significant psoriasin gene and protein expression when applied to artificially generated skin wounds in vivo. The observed psoriasin induction in keratinocytes may contribute to the wound healing-promoting effects of therapeutically used thrombocyte concentrate lysates.
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Authors
Andreas Bayer, Justus Lammel, Sebastian Lippross, Tim Klüter, Peter Behrendt, Mersedeh Tohidnezhad, Thomas Pufe, Jochen Cremer, Holger Jahr, Franziska Rademacher, Regine Gläser, Jürgen Harder,