The clinical efficacy of primary culture of human fibroblasts in gingival augmentation procedures-A preliminary report

Clinically, over a 6 month period of observation, a significant decrease in the distance from cemento-enamel junction to mucogingival junction (CEJ-MGJ) was revealed. Histologically, mature connective tissue covered by keratinized epithelium was found after 12 weeks. No specimens revealed an inflammatory response. A complete clinical healing was observed after 2 weeks in eight patients [early healing index (EHI) = I]. The results of clinical evaluation indicate that the method of primary culture of human fibroblasts on a collagenous carrier for gingival augmentation is an esthetic and effective method of mucogingival complex repair. The scaffolds were substituted and completely re-epithelialized within 12 weeks according to histologic results.