Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8462579 | Annals of Anatomy - Anatomischer Anzeiger | 2009 | 10 Pages |
Abstract
After the treatment of hPSCs with RA, a strong induction of α-SMA protein expression was observed when 2 mM RA was added to the medium. DMSO in turn induced a marked reduction in α-SMA-positive cells. This could also be observed using a keratinocyte serum-free medium (KSFM). Furthermore, the general addition of FCS to the medium had a blocking effect on α-SMA expression and decreased the number of α-SMA-positive cells to a minimum. The controlled modulation of hPSCs by soluble factors is a first success on the way to a promising application for transplantation medicine and cell therapy of degenerative diseases.
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Authors
Anna Emilia Petschnik, Philipp Ciba, Charli Kruse, Sandra Danner,