Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8462661 | Annals of Anatomy - Anatomischer Anzeiger | 2008 | 7 Pages |
Abstract
The total cell number in the neocortical part of four DS human fetal forebrain was found to be substantially smaller in DS compared to the normal fetus. The average total cell number of 6.85 billion was equal to a reduction by 34% compared to the 10.4 billion cells in a normal fetal brain of that age. This study indicates that the mental retardation found in DS is based on a structural deficit in the human fetal brain already present in the second trimester.
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Authors
Karen Bonde Larsen, Henning Laursen, Niels Græm, Grethe Badsberg Samuelsen, Nenad Bogdanovic, Bente Pakkenberg,