Novel localization of tenascin-X in adult mouse leptomeninges and choroid plexus

Tenascin-X (Tn-X) belongs to the tenascin family of glycoproteins and is clearly associated with the human connective tissue disorder Ehlers-Danlos syndrome. Recently, human single nucleotide polymorphism analyses showed that Tn-X is associated with schizophrenia. Tn-X-related central nervous system (CNS) disorder has been reported in recent years. However, details of Tn-X localization are not clear in the adult cerebral cortex and its meninges. Using immunohistochemical techniques, we found novel localizations of Tn-X in the leptomeningeal trabecula (TB) of adult mice and in the connective tissue of the choroid plexus (CP) in the brains of mice. Subsequent immunohistochemical studies showed complementary localization of Tn-X in the leptomeninges and CP. Localization of tenascin-C was not detected in the leptomeningeal TB or in the connective tissue of the CP. These results might provide insight into the role of Tn-X in the pathogenesis of disorders in the CNS.