The posttraumatic activation of CD4+ T regulatory cells is modulated by TNFR2- and TLR4-dependent pathways, but not by IL-10

Article ID	Journal	Published Year	Pages	File Type
8463526	Cellular Immunology	2018	9 Pages	PDF

Abstract

TLR4- and TNFR2-dependent mechanisms, but not IL-10-dependent pathways, modulate the anti-inflammatory response of CD4+ Tregs following trauma.

Keywords

MFI PKC-Θ Protein kinase C-θ MODS TNFR2 TBSA SIRS TLR4 IL-10 TCr Cell communication Interleukin-10 Trauma Rotational thromboelastometry Total body surface area Regulatory T cells Multiple organ dysfunction syndrome Systemic inflammatory response syndrome Compensatory anti-inflammatory response syndrome CARS mean fluorescence intensity wild type Hemostasis Adaptive immune response Platelets T cell receptor tumor necrosis factor receptor 2

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Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology

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The posttraumatic activation of CD4+ T regulatory cells is modulated by TNFR2- and TLR4-dependent pathways, but not by IL-10

Authors

Matthias Bock, Christian B. Bergmann, Sonja Jung, Miriam Kalbitz, Borna Relja, Stefan Huber-Wagner, Peter Biberthaler, Martijn van Griensven, Marc Hanschen,