Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8463685 | Cellular Immunology | 2016 | 4 Pages |
Abstract
Avian H7N9 influenza virus infection with fatal outcomes continues to pose a pandemic threat and highly immunogenic vaccines are urgently needed. In this report we show that baculovirus-derived recombinant H7 hemagglutinin protein, when delivered with RIG-I ligand, induced enhanced antibody and T cell responses and conferred protection against lethal challenge with a homologous H7N9 virus. These findings indicate the potential utility of RIG-I ligands as vaccine adjuvants to increase the immunogenicity of recombinant H7 hemagglutinin.
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Authors
Weiping Cao, Justine S. Liepkalns, Ram P. Kamal, Adrian J. Reber, Jin Hyang Kim, Amelia R. Hofstetter, Samuel Amoah, James Stevens, Priya Ranjan, Shivaprakash Gangappa, Ian A. York, Suryaprakash Sambhara,