| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8463787 | Cellular Immunology | 2015 | 5 Pages |
Abstract
What are the minimum specificity requirements of a thymic selective process that establishes (1) restrictive recognition of peptide, (2) the Self (S)-Nonself (NS) discrimination, and (3) the categories of effector function? Given an answer to that question, how well does it fit with the observed selective processes in thymus where T-cells are generated? Any discrepancies between the two must be rationalized. The goal of this essay is to attempt just that.
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Authors
Melvin Cohn,