Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8463825 | Cellular Immunology | 2014 | 9 Pages |
Abstract
Extracellular adenosine is an essential negative regulator of immune reactions that acts by signaling via 4 distinct adenosine receptors. We evaluated adenosine receptor expression in Lewis rats presenting with experimental autoimmune myasthenia gravis (EAMG) to determine whether the expression of adenosine receptors are changed in the development and progression of EAMG. Lymphocyte A1AR and A2AAR mRNA and protein levels from lymphocytes harvested from the lymph nodes, spleen, and peripheral blood mononuclear cells (PBMCs) of EAMG rats were decreased. A modest but not significant increase in A2BAR levels was observed in EAMG lymphocytes harvested from lymph nodes and PBMCs. No changes in A3AR expression were observed in lymphocytes harvested from lymph nodes, spleen, or PBMCs following EAMG induction. Results presented in this report showed that the expression levels and the distribution pattern of adenosine receptors were altered in EAMG lymphocytes.
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Authors
Na Li, Geng Wang, Xiuhua Yao, Qingfei Kong, Xiaoyu Shang, Xiaoli Xie, Jinghua Wang, Xiaoying Kang, Lianhong Jin, Guangyou Wang, Hulun Li, Lili Mu, Bo Sun,