Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8463831 | Cellular Immunology | 2014 | 6 Pages |
Abstract
Paraneoplastic neurological syndromes (PNS) are associated with small cell lung cancer (SCLC) and Hu antibodies, which are considered to have an immune-mediated etiology. As a pathogenic role for Hu antibodies (Hu-Ab) in PNS could not be demonstrated, the cellular immune response against the Hu proteins has been further investigated. To delve deeper into the hypothesized cell-mediated immune pathogenesis of these syndromes, imbalances within circulating T lymphocyte subsets were investigated to determine their significance in Hu antibody-associated PNS. The circulating T lymphocyte subsets were analyzed in untreated patients with SCLC, PNS and Hu-Ab (n = 10), SCLC without PNS (n = 10) and healthy controls (n = 12) using flow cytometry. Patients with PNS and SCLC, had a variety of changes within their circulating T lymphocyte subsets, which included; lymphopenia of the CD3+and CD4+ T cells, increased proportions of total activated T cells and activated CD4+ T cells, and reduced numbers of CD4+ and CD25+ regulatory T cells (Treg). These results suggest that the excessive activation of T cells and dysfunction of Treg contribute to Hu antibody-associated PNS.
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Authors
Lina Zhang, Weidong Qian, Qiming Chen, Liang Yin, Baiqing Li, Hongtao Wang,