Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8463840 | Cellular Immunology | 2014 | 6 Pages |
Abstract
The aim of this study was to clarify the role of IL-4, IL-10, IL-13 and interferon (IFN) -γ levels in atopic asthma patients by studying the relation between their serum levels and severity of the disease. The effect of IL-10 â1082G/A and IFN-γ +874T/A SNPs was also studied. The study included 200 atopic children with asthma and 50 age- and gender matched healthy children as controls. The levels of both IL-4 and IL-13 were significantly (p < 0.001) higher, while IFN-γ was significantly (p < 0.001) lower in patients compared to that of the controls. There was a significant effect of gene polymorphisms of IL-10 (p < 0.05) and IFN-γ (p < 0.001) in occurrence of atopic asthma and increased IgE level. Polymorphism of IFN-γ gene had an effect on the serum level of IFN-γ. In conclusion, IFN-γ gene polymorphism at position +874 and IL-10 gene polymorphism at position â1082A/G are genetic determinants which contribute to susceptibility to atopic asthma in children from Saudi Arabia.
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Authors
Y.M. Hussein, S.S. Alzahrani, A.A. Alharthi, M.M. Ghonaim, A.S. Alhazmi, E.M. Eed, S.M. Shalaby,