| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8463936 | Cellular Immunology | 2012 | 9 Pages |
Abstract
⺠We investigated the effects of L-Arg depletion on NK cell functions. ⺠L-Arg depletion decreases NK cell proliferation, cytotoxicity and IFN-γ production. ⺠L-Arg deficiency altered NKp46, NKp30 and ζ chain expression. ⺠This reduced NK functions may be involved in the tumor immune escape.
Keywords
phorbol 12-myristate 13-acetatePC5PLSDKiller Ig-like receptorsODCOrnithine decarboxylaseMDSCCD25KireNOSMFIiNOSeGFPCATPMAl-argininel-ArgOatprotected least significant differencecationic amino acid transporterMyeloid-derived suppressor cellsNK cellsCytotoxicityinducible nitric-oxide synthasephycoerythrinmean fluorescence intensityenhanced green fluorescent proteinPropidium iodideActivating receptors
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Authors
Bruno Lamas, Juliette Vergnaud-Gauduchon, Nicolas Goncalves-Mendes, Olivier Perche, Adrien Rossary, Marie-Paule Vasson, Marie-Chantal Farges,