| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8463944 | Cellular Immunology | 2012 | 10 Pages |
Abstract
⺠A bacterial toxin (SEB) causes memory CD4 T cell inactivation (anergy). ⺠We show that anergy is dependent upon activation of Fyn kinase. ⺠Inhibition or loss of Fyn kinase prevents anergy. ⺠We show that Fyn associates with c-Cbl in response to SEB. ⺠Fyn/c-Cbl complexes prevents ZAP-70 from binding to the TCR/CD3 complex.
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Authors
Andrew R.O. Watson, David K. Janik, William T. Lee,