| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8463953 | Cellular Immunology | 2012 | 10 Pages |
Abstract
⺠Lupus mice lacking NOS2 or NOS3 developed lesions in the aortic adventitia. ⺠The lesions displayed SK1, macrophage infiltration and oxLDL-IC accumulation. ⺠NOS2 or NOS3 deletion in lupus mice decreased levels of anti-inflammatory IL-10. ⺠Plasma levels of ceramide species and pro-inflammatory S1P were increased. ⺠Restoration of NOS3 function may be a future approach in the treatment of lupus.
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Authors
Mohammed M. Al Gadban, Jashalynn German, Jean-Philip Truman, Farzan Soodavar, Ellen C. Riemer, Waleed O. Twal, Kent J. Smith, Demarcus Heller, Ann F. Hofbauer, Jim C. Oates, Samar M. Hammad,