| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8463963 | Cellular Immunology | 2012 | 8 Pages |
Abstract
⺠HLA-B locus was selectively down-regulated in post-transplant leukemia blasts. ⺠All isolated cytotoxic T lymphocyte (CTL) clones recognized the HLA-Bâ51:01 molecule. ⺠Pretransplant leukemia blasts were lysed by CTLs, but post-transplant blasts were not. ⺠Bâ51:01-reactive CTLs were detected in patient blood just before relapse. ⺠Our data indicate leukemia escape from immunological pressure by HLA-specific CTLs.
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Authors
Tomonori Kato, Seitaro Terakura, Makoto Murata, Kyoko Sugimoto, Miho Murase, Chisako Iriyama, Akihiro Tomita, Akihiro Abe, Momoko Suzuki, Tetsuya Nishida, Tomoki Naoe,