Article ID Journal Published Year Pages File Type
8463975 Cellular Immunology 2012 8 Pages PDF
Abstract
► We reveal the post-transcriptional control of IFN-alpha production in cord blood. ► Cord blood plasmacytoid dendritic cells exhibit a profound defect in IFN-a production. ► This defect correlates with the lower expression of proteins within the TLR9 pathway. ► We also observed a higher expression of miR-146a and miR-155. ► Although, cord blood PDC are mature and differentiate in antigen-presenting cells.
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