Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8463975 | Cellular Immunology | 2012 | 8 Pages |
Abstract
⺠We reveal the post-transcriptional control of IFN-alpha production in cord blood. ⺠Cord blood plasmacytoid dendritic cells exhibit a profound defect in IFN-a production. ⺠This defect correlates with the lower expression of proteins within the TLR9 pathway. ⺠We also observed a higher expression of miR-146a and miR-155. ⺠Although, cord blood PDC are mature and differentiate in antigen-presenting cells.
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Authors
Emily Charrier, Paulo Cordeiro, Martine Cordeau, R'Kia Dardari, Annie Michaud, Michaël Harnois, Natacha Merindol, Sabine Herblot, Michel Duval,