Article ID Journal Published Year Pages File Type
8464664 Current Opinion in Cell Biology 2018 9 Pages PDF
Abstract
Since their recent development, organoids that emulate human brain tissue have allowed in vitro neural development studies to go beyond the limits of monolayer culture systems, such as neural rosettes. We present here a review of organoid studies that focuses on cortical wall development, starting with a technical comparison between pre-patterning and self-patterning brain organoid protocols. We then follow neocortex development in space and time and list those aspects where organoids have succeeded in emulating in vivo development, as well as those aspects that continue to be pending tasks. Finally, we present a summary of medical and evolutionary insight made possible by organoid technology.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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