| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8464705 | Current Opinion in Cell Biology | 2018 | 8 Pages |
Abstract
The planar cell polarity (PCP) pathway controls a variety of morphological events across many species. During embryonic development, the PCP pathway regulates coordinated behaviour of groups of cells to direct morphogenetic processes such as convergent extension and collective cell migration. In this review we discuss the increasingly prominent role of the PCP pathway in organogenesis, focusing on the lungs, kidneys and heart. We also highlight emerging evidence that PCP gene mutations are associated with adult diseases.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Deborah J Henderson, David A Long, Charlotte H Dean,