Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8464990 | Current Opinion in Cell Biology | 2017 | 7 Pages |
Abstract
Cells of terrestrial animals are constantly exposed to external forces including gravity. However, the complex 3D structure of the body and its organs form without being flattened. A century ago, the mathematical biologist D'Arcy Thompson predicted in 'On Growth and Form' that terrestrial animal body shapes are entirely conditioned by gravity [1], but the prediction remained to be proved due to the lack of an appropriate animal model. In this review, we outline a new mechanism of morphogenesis which ensures the generation of vertebrate 3D body shape that can withstand gravity and in which Hippo-YAP signaling acts as a mechano-effector controlling mechano-homeostasis. We will highlight the recent papers that advanced the field and discuss the impact of this previously unrecognized function of YAP-mediated signaling on the established concept of organogenesis, tissue homeostasis and disease.Current Opinion in Cell Biology 2017, 49:64-70This review comes from a themed issue on Cell differentiation and diseaseEdited by Magdalena Gotz and Senthil MuthuswamyFor a complete overview see the Issue and the EditorialAvailable online 15th December 2017https://doi.org/10.1016/j.ceb.2017.11.0130955-0674/© 2017 Elsevier Ltd. All rights reserved.
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Authors
Yoichi Asaoka, Makoto Furutani-Seiki,