Article ID Journal Published Year Pages File Type
8465513 Current Opinion in Cell Biology 2015 9 Pages PDF
Abstract
Adherent cells migrate and change their shape by means of protrusion and retraction at their edges. When and where these activities occur defines the shape of the cell and the way it moves. Despite a great deal of knowledge about the structural organization, components, and biochemical reactions involved in protrusion and retraction, the origins of their spatial and temporal patterns are still poorly understood. Chemical signaling circuitry is believed to be an important source of patterning, but recent studies highlighted mechanisms based on physical forces, motion, and mechanical feedback.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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