Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8465544 | Current Opinion in Cell Biology | 2015 | 7 Pages |
Abstract
Totipotent and pluripotent cells display different degrees of cellular plasticity. After fertilization, embryonic cells transit naturally from a totipotent to a pluripotent state. Major changes in nuclear architecture, chromatin mobility and gene expression occur during this transition. In particular, nuclear architecture has recently emerged as a potential regulator of heterochromatin formation in the early embryo. Future research should address whether a causal, functional link between nuclear organization and gene regulation is a general theme during reprogramming and the formation of pluripotent cells.
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Authors
Thanh Quang Dang-Nguyen, Maria-Elena Torres-Padilla,