Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8465658 | Current Opinion in Cell Biology | 2015 | 8 Pages |
Abstract
Mitochondria govern many metabolic processes. In addition, mitochondria sense the status of metabolism and change their functions to regulate energy production, cell death, and thermogenesis. Recent studies have revealed that mitochondrial structural remodeling through division and fusion is critical to the organelle's function. It has also become clear that abnormalities in mitochondrial division and fusion are linked to the pathophysiology of metabolic diseases such as diabetes and obesity. Here, we discuss the current understanding of the mechanisms of mitochondrial dynamics and their role in cellular and organismal metabolism.
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Authors
Madhuparna Roy, P Hemachandra Reddy, Miho Iijima, Hiromi Sesaki,