| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8465840 | Current Opinion in Cell Biology | 2014 | 7 Pages |
Abstract
The biogenesis of autophagosomes entails the nucleation and growth of a double-membrane sheet, the phagophore, which engulfs cytosol for delivery to the lysosome. Genetic studies have identified a class of Atg proteins that are essential for the process, yet the molecular mechanism of autophagosome biogenesis has been elusive. Proteomic, structural, super-resolution imaging, and biochemical reconstitution experiments have begun to fill in some of the gaps. This review describes progress and prospects for obtaining a four-dimensional network model of the nucleation and growth of the phagophore.
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Authors
Liang Ge, Sulochanadevi Baskaran, Randy Schekman, James H Hurley,