| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8465990 | Current Opinion in Cell Biology | 2014 | 9 Pages |
Abstract
- Single-molecule imaging in live cells revealed GPCR dimer-monomer equilibrium.
- GPCRs continually form transient monomers and homo-dimers with different partners.
- GPCR homo-dimers dissociate into monomers on the time scale of 0.1 s at 37 °C.
- The monomer-dimer equilibrium was fully characterized by single-molecule imaging.
- Single-molecule imaging is powerful for elucidating signal transduction mechanisms.
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Authors
Rinshi S Kasai, Akihiro Kusumi,