Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8466017 | Current Opinion in Cell Biology | 2014 | 8 Pages |
Abstract
Many G protein-coupled receptors (GPCRs) internalize after agonist-induced activation. While endocytosis has long been associated with homeostatic attenuation of cellular responsiveness, accumulating evidence from study of a wide range of eukaryotes reveals that the endocytic pathway also contributes to generating receptor-initiated signals themselves. Here we review recent progress in this area, discussing primarily but not exclusively GPCR signaling in mammalian cells.
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Authors
Roshanak Irannejad, Mark von Zastrow,