| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8466112 | Current Opinion in Cell Biology | 2014 | 8 Pages |
Abstract
- Spatial sequestration of misfolded proteins is an early, normal response to stress.
- PQC compartments spatially restrict misfolded proteins thus enhancing degradation.
- The ER acts as a dynamic network for the spatial distribution of misfolded proteins.
- Spatial protein sequestration promotes rejuvenation of daughter cells in mitosis.
- Altered PQC is associated with neurodegenerative disorders, cancer, and aging.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Emily M Sontag, Willianne IM Vonk, Judith Frydman,