Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8466169 | Current Opinion in Cell Biology | 2008 | 9 Pages |
Abstract
The nuclear envelope (NE) provides a selective barrier between the nuclear interior and the cytoplasm and constitutes a central component of intracellular architecture. During mitosis in metazoa, the NE breaks down leading to the complete mixing of the nuclear content with the cytosol. Interestingly, many NE components actively participate in mitotic progression. After chromosome segregation, the NE is reassembled around decondensing chromatin and the nuclear compartment is reestablished in the daughter cells. Here, we summarize recent progress in deciphering the molecular mechanisms underlying NE dynamics during cell division.
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Authors
Ulrike Kutay, Martin W Hetzer,