Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8466514 | Cytokine & Growth Factor Reviews | 2016 | 37 Pages |
Abstract
This review describes the unique role of STAT2 in differential complex formation of unphosphorylated and phosphorylated ISGF3 components that direct constitutive and IFN-I-stimulated transcriptional responses. In addition, we highlight the existence of a STAT1-independent IFN-I signaling pathway, where STAT2/IRF9 can potentially substitute for the role of ISGF3 and offer a back-up response against viral infection.
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Authors
Katarzyna Blaszczyk, Hanna Nowicka, Kaja Kostyrko, Aleksandra Antonczyk, Joanna Wesoly, Hans A.R. Bluyssen,