Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8466975 | Cytotherapy | 2018 | 17 Pages |
Abstract
6-OHDA induced apoptosis in MSCs via generation of H2O2, activation of c-JUN and PUMA, mitochondrial depolarization and nuclei fragmentation. Our findings suggest that PARKIN protects MSCs against 6-OHDA toxicity by partly interacting with H2O2, reducing the expression of c-JUN, PUMA, AIF and caspase-3, and maintaining the mitochondrial ÎΨm.
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Authors
A.R. Bonilla-Porras, A. Arevalo-Arbelaez, J.F. Alzate-Restrepo, C. Velez-Pardo, M. Jimenez-Del-Rio,