Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8467125 | Developmental Biology | 2018 | 39 Pages |
Abstract
The Hippo signaling pathway is implicated in key aspects of cell proliferation, control of organ size, stem cell functions and tumor suppression. Its functions are primarily mediated either through direct effects on transcription factors to influence target gene expression or through crosstalk with other signaling pathways that regulate multiple physiological activities. Studies are revealing Hippo pathway involvement in diverse functions including renewal of intestinal epithelium, promotion of myocardial cell proliferation, cancer suppression, etc. In this review we discuss Hippo pathway signaling in oral-maxillofacial development and bone remodeling under normal and pathological conditions and highlight promising future research directions.
Keywords
TEADsSSCsSAVosterixTAZOCNScribECMTGFRunxGLUT1Oral developmentGPCRTFslarge tumor suppressor kinaseMSTOSCCCTGFOsteocalcinOsxYAPbone remodelingtransforming growth factorEpithelial-mesenchymal transformationParMaxillofacial developmentEMTShhKaposi's sarcomaSalvadorSjögren's syndromesonic hedgehogrunt-related transcription factorTranscription factorsConnective tissue growth factorLatsExtracellular matrixBMPHippo pathwayyes-associated proteinBone morphogenetic proteinoral squamous cell carcinomaScribbleglucose transporter 1protease-activated receptorG protein-coupled receptor
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Authors
Lin Xiang, Hui Yu, Xinyuan Zhang, Bin Wang, Ying Yuan, Qin Zhang, Rui Ye, Ping Gong, Yingying Wu,