| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8467797 | Developmental Biology | 2017 | 15 Pages |
Abstract
The opposing effects of Slit/Robo and Netrin-1/DCC signals were tested genetically by combining Netrin-1 and Robo1/2 mutations. The location of exit points in the combined mutants was significantly recovered to their normal position compared to Netrin-1 or Robo1/2 mutants. Together, these results suggest that the proper position of motor exit points is determined by a “push-pull” mechanism, pulled ventrally by Netrin-1/DCC attraction and pushed dorsally by Slit/Robo repulsion.
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Authors
Minkyung Kim, Tatiana M. Fontelonga, Clare H. Lee, Sarah J. Barnum, Grant S. Mastick,