Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8468059 | Developmental Biology | 2013 | 15 Pages |
Abstract
Our results demonstrate that the Tg(4xE-box:Luc) line is an excellent tool for studying the regulation of the circadian clock and its maturation in vivo and in real time. Furthermore, it is highly suitable for in vivo screens targeting the core clock mechanism that take into account the complexity of an intact organism. Finally, it allows mapping of clock activity in the brain of a vertebrate model organism with prominent adult neurogenesis and high regeneration capacity.
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Authors
Meltem Weger, Benjamin D. Weger, Nicolas Diotel, Sepand Rastegar, Tsuyoshi Hirota, Steve A. Kay, Uwe Strähle, Thomas Dickmeis,