| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8468112 | Developmental Biology | 2011 | 12 Pages |
Abstract
⺠lin-6 mutants are defective in DNA synthesis but continue mitosis during postembryonic development. ⺠The lin-6 gene encodes the C. elegans homologue of the MCM-4 subunit of the MCM2-7 replicative helicase complex. ⺠lin-6/mcm-4 is required for checkpoint function when DNA replication is incomplete. ⺠lin-6/mcm-4 is specifically required in the epidermis for postembryonic growth and viability.
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Authors
Jerome Korzelius, Inge The, Suzan Ruijtenberg, Vincent Portegijs, Huihong Xu, H. Robert Horvitz, Sander van den Heuvel,