| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8468124 | Developmental Biology | 2011 | 15 Pages |
Abstract
âºThe Notch pathway is active in the optic lobe neuroepithelium. âºNotch or Delta mutant brains developed no lamina and an undersized medulla due to early depletion of neuroepithelial stem cells in the optic lobe. âºMosaic clone analyses indicate that the Delta/Notch/Su(H) pathway is required for both maintaining the neuroepithelial stem cells and inhibiting medulla neuroblast formation while E(spl)-C is only involved in the inhibition of medulla neuroblast formation. âºNotch pathway overactivation promotes neuroepithelial cell overexpansion. âºnumb loss of function mimics Notch overactivation.
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Authors
Wei Wang, Wenke Liu, Yue Wang, Liya Zhou, Xiaofang Tang, Hong Luo,