| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8468149 | Developmental Biology | 2011 | 9 Pages |
Abstract
⺠The canonical Wnt signaling activity is detected in the MEE of developing palate. ⺠Epithelial inactivation of Catnb causes Tgfβ3 downregulation and clefting of palate. ⺠Exogenous Tgfβ3 rescues fusion defect of the K14Cre;CatnbF/F palate in vitro. ⺠Ectopic activation of Wnt canonical signaling leads to ectopic Tgfβ3 expression. ⺠Wnt/β-catenin signaling acts in the palatal epithelium to control palate fusion.
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Authors
Fenglei He, Wei Xiong, Ying Wang, Lu Li, Chao Liu, Takashi Yamagami, Makoto M. Taketo, Chengji Zhou, YiPing Chen,