Impact du changement de standard international d'hCG sur le dépistage de la trisomie 21 fœtale par les marqueurs sériques maternels (application aux réactifs AxSYM®, Abbott)

The determination of maternal serum markers between fourteenth and eighteenth week of pregnancy allows to estimate an individual risk for fetal Down's syndrome. Serum α-fetoprotein (AFP) and human chorionic gonadotropin (hCG) concentrations were measured using AxSYM® Abbott and expressed in multiple of the median (MoM). The risk calculation is obtained with Maciel Interpretive Software. The modification of the international standard of hCG reduces the hCG values, so the median values are no longer appropriate. We studied 377 serum and established a correlation between the values obtained from the two calibrations. New medians were calculated and applied from 1st January 2007. The reanalysis of the 377 cases did not show any discrepancy in the screening performance.