Anticorps antigliadine et anticorps antiendomysium : détection et valeur diagnostique dans la maladie cœliaque

The aim of this study was to search simultaneously for antiendomysium and antigliadin by indirect immunofluorescence in a group of coeliac children and a control. The significance in detection and supervision coeliac disease because there is a best correlation between development there titre and development clinical there disease. Thirty patient sex mixed age six to eight years were examined for coeliac disease. In active coeliac disease, the sensitivity of IgG antigliadin, IgA antigliadin and antiendomysium was 90, 65 and 95% respectively. Their specificity was 100%. They were never detected in case of characteristic patients. The association of AAG and/or AEM allow better result for coeliac disease depistage with of sensitivity 95% and specificity 100%. Under a strict gluten free diet, the prevalence AAG/IgG and AEM were 10 and 20% respectively. In suspect coeliac disease the AAG/IgG, AAG/IgA and AEM were absent. The significance association of AAG and/or AEM is important in coeliac disease.